Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models.

CD8+ infiltration was significantly lower in p53 -GOF SCCs than in p53 -LOF SCC ( Figure 2 C), and lower than that of p53 -WT SCCs, although this difference did not reach statistical significance, as high variability among samples was observed in the p53 -WT tumors ( Figure 2 C).

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Scores for other cell populations, such as macrophages and neutrophils, also showed a trend to be lower in p53 -GOF lesions, although the differences were not statistically significant ( Figure 6 D).

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