Although baseline renal function was not statistically different between these two groups, the LMWD group demonstrated a strong trend toward the progression of renal insufficiency as indicated by the greater change in serum creatinine level during the 1-year follow-up compared with the control group.
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Low-molecular-weight dextran for optical coherence tomography may not be protective against kidney injury in patients with renal insufficiency.
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DISCUSSION The main findings of the present study are: (1) The additional use of LMWD for OCT was identified in 18.8% (79/421) of the study patients with advanced renal insufficiency; (2) The LMWD group demonstrated a strong trend toward the progression of renal insufficiency as indicated by the greater change in serum creatinine level during the 1-year follow-up compared with the control group; (3) After propensity score matching, the LMWD group demonstrated a significant trend in the progression of renal insufficiency at the 1-year follow-up; and (4) Multivariable logistic regression analysis revealed that greater LMWD volume and lower baseline eGFR level were independently associated with worsening renal function in the propensity score-matched cohort.