Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice.

While not reaching statistical significance, there was a clear trend towards reduced corneal opacity in all MSC treatment groups versus PBS-treated control mice (PBS v allo-MSC (D−1, D+1): p = 0.0717; PBS v allo-MSC (D−1): p = 0.0699; PBS v allo-MSC (D+1): p = 0.0641) (Fig. 2 b).

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qRT-PCR analysis of dLNs also showed a trend towards an increase in TGF-β mRNA expression (though not statistically significant) in allo-MSC-treated animals (Fig. 3 g).

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