Manipulation of EGFR-Induced Signaling for the Recruitment of Quiescent Neural Stem Cells in the Adult Mouse Forebrain.

Western blots showed that the V-SVZ of 4-month-old animals had a 55.5% decrease in PCNA expression (1 month, 0.18 ± 0,02 AU versus 4 months, 0.08 ± 0.01 AU, n = 4, p = 0.007, Unpaired t -test) that was accompanied by statistically significant downregulations of pAKT (27.4% decrease between 1 month, 0.51 ± 0.04 AU and 4 months, 0.37 ± 0.03 AU, n = 4 per age group, p = 0.03, Unpaired t -test) and p4EBP1 (51.5% decrease between 1 month, 0.68 ± 0.13 AU and 4 months, 0.33 ± 0.04 AU, n = 4 per age group, p = 0.03, Unpaired t -test) and a strong trend for pS6 (47.4% decrease between 1 month, 0.5731 ± 0.1223 AU and 4 months, 0.30 ± 0.05 AU, n = 4 per age group, p = 0.07, Unpaired t -test) ( Figure 1F ).

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Consistent with this, the proportion of pS6 + cells that incorporated EdU showed a trend toward a decrease ( Figure 5H ).

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