Concomitant mutation status of <i>ALK</i>-rearranged non-small cell lung cancers and its prognostic impact on patients treated with crizotinib.

Transl Lung Cancer Res · 2021 · PMC8044492 · PMID 33889527

Europe PMC DOI

hedged sentences

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

showed a trendP=0.064so close (0.05 < p ≤ 0.1)

Survival analyses revealed that patients concurrently harboring PIK3R2 alterations showed a trend toward shorter progression-free survival (6 vs. 13 months, P=0.064) and significantly shorter overall survival (11 vs. 32 months, P=0.004) than did PIK3R2 -wild-type patients.

also in 53,322 other papers

hugely significantno p-value reported

Similar to that of Kirsten rat sarcoma viral oncogene homolog ( KRAS ) and epidermal growth factor receptor ( EGFR ), the discovery of echinoderm microtubule-associated protein-like 4 fused with anaplastic lymphoma kinase ( EML4 - ALK ) has been hugely significant to the individualized treatment of NSCLC.

also in 172 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.