Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

For example, complement C5 was found to have 11 peptides approaching significance (q < 0.25) in our linear mixed model ( Fig. 1A-L ), with similar trends for peptides from both its alpha and beta subunits.

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In addition to the complement peptides that dif-fered between groups, several non-complement factors with known pro-inflammatory and/or hemostatic functions were identified by our linear mixed models as trending toward significance (q < 0.25) between the patients with versus without POCD over the six-week period.

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Second, over the course of six weeks, there was a clear trend toward convergence of these peptide intensities for all of the proteins except complement factor H, which further diverged by the six-week time point.

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