Barely Significant
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Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans.

Immun Ageing · 2021 · PMC8053564 · PMID 33874975

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closest p · 2.0× alpha
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showed a trendp = 0.1so close (0.05 < p ≤ 0.1)
Interestingly, following Ty21a immunization, LPMC CD8+ T Naive showed statistically significant ( p < 0.05) lower levels in the elderly as compared to adult volunteers while CD8+ T EM showed a trend ( p = 0.1) to exhibit increases in the elderly compared to adult volunteers following Ty21a immunization (Fig. 1 b).

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Similar to the data reported by Lin et al., 2016 [ 34 ], we observed that the ratio of CD4/CD8 in PBMC appears to increase with age in our Baltimore cohort; however, these changes did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.