Lysergic acid diethylamide differentially modulates the reticular thalamus, mediodorsal thalamus, and infralimbic prefrontal cortex: An in vivo electrophysiology study in male mice.

When haloperidol was administered following cumulative doses of LSD, we observed a trend towards a further increase in cell firing frequency of pyramidal IL-PFC neurons compared with LSD 160 μg/kg, which did not reach statistical significance ( F 2, 10 = 8.304, p = 0.0075, post-hoc test compared with LSD 160 μg/kg p = 0.0512; Figure 5(m) and ( n )).

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The dopamine D2 receptor (D 2 ) antagonist haloperidol administered after LSD increased burst-firing activity in the reticular thalamus neurons inhibited by LSD, decreased firing and burst-firing activity in the mediodorsal thalamus, and showed a trend towards further increasing the firing activity of neurons of the infralimbic prefrontal cortex.

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