Plasma heat shock protein response to euglycemia in type 2 diabetes.

Following glucose normalization, DnaJ homolog subfamily B member 1 (DNAJB1 or HSP40) was reduced (p=0.02) in T2D, with HSP beta-1 (HSPB1) and HSP-70-1A (HSP70-1A) (p=0.07 and p=0.09, respectively) also approaching significance relative to T2D baseline levels.

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On achieving euglycemia in T2D subjects, HSPB1, a chaperone protein involved in protection of the proteome from stress, and HSP70-1A, a protein member of the HSP70 family also involved in protection of the proteome from stress by targeting and direction of misfolded proteins for either refolding or degradation, also approached significance relative to baseline levels.

also in 8,237 other papers