MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation.

A similar increasing trend was observed in the levels of nitrite, the primary breakdown product of NO, but this did not reach statistical significance ( Figure 2 d).

also in 111,027 other papers

Concomitantly, the cytotoxicity assay showed a decreasing trend in the co-cultures of BV2 cells and the MECP2-WT or MECP2-S423A expressing neurons when compared to the control co-cultures.

also in 47,180 other papers

Finally, elucidation of relevant AD-associated metadata available from the post-mortem tissue cohort [ 27 ] in relation to RNA, protein, and phosphorylation changes of MECP2, revealed a nominally significant negative correlation between the levels of Aβ42 in the CSF and the MECP2 RNA levels in the temporal cortex.

also in 7,732 other papers