Towards Novel Treatments for Schizophrenia: Molecular and Behavioural Signatures of the Psychotropic Agent SEP-363856.

Int J Mol Sci · 2021 · PMC8073823 · PMID 33923479

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0.0000

closest p · 0.0× alpha

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tendency towards significancep = 1.88 × e −57actually significant

Repeated measures ANOVA showed a significant main effect of time and treatment, but only a slight tendency towards significance for time*treatment interaction (main effect of time: F(7.860,337.984) = 56.832, p = 1.88 × e −57 , ηp 2 = 0.569; main effect of treatment: F(4,43) = 5.973, p = 0.0006, ηp 2 = 0.357; time*treatment: F(31.440,337.984) = 1.396, p = 0.082, ηp 2 = 0.115).

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almost significantp = 0.061so close (0.05 < p ≤ 0.1)

Moreover, when analysing the total counts during the first 60 min of the test ( Figure 5 B), univariate ANOVA showed an almost significant effect of drug treatment (F(3,44) = 2.643, p = 0.061).

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did not reach statistical significancep = 0.231not close (p > 0.1)

Specifically, this effect was significant for the lowest and highest doses of the compound (1 and 10 mg/kg, p < 0.01), while the increase observed in animals treated with SEP-856 at 3 mg/kg did not reach statistical significance ( p = 0.231).

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