Trastuzumab administration during pregnancy: an update.

BMC Cancer · 2021 · PMC8074427 · PMID 33902516

Europe PMC DOI

hedged sentences

0.3110

closest p · 6.2× alpha

0.3160

boldest claim

The sentences

failed to reach statistical significanceP = 0.311not close (p > 0.1)

In addition, a completely healthy neonate was born in 75% of cases that trastuzumab treatment affected only the first trimester in contrast with 41.7% of cases where the fetus was exposed during second and/or third trimester as well, although this association failed to reach statistical significance ( P = 0.311; Fisher’s exact test).

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did not reach statistical significanceP = 0.316not close (p > 0.1)

The trend pointing to a positive association between the duration of trastuzumab treatment and the development of oligohydramnios or anhydramnios did not reach statistical significance (OR = 1.05, 95% CI: 0.96–1.14, increment: 1 week, P = 0.316).

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