Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy.

In the analysis for TIM3, CAR-αPD-1 and CD19 CAR-Trap showed a trend toward the inhibition of TIM3 upregulation, but it did not reach statistical significance ( Figure 5 D).

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