Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis.

Sci Rep · 2021 · PMC8085032 · PMID 33927270

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a clear trendno p-value reported

However in all groups, there was a clear trend towards a reduction in the likelihood of pre-eclampsia in women randomised to metformin compared to any other treatment.

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did not reach statistical significanceno p-value reported

This did not reach statistical significance likely because of insufficient data when each indication for treatment was considered separately.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.