While CD4+ and CD8+ T cell populations did not differ between genotypes, NKT (natural killer T) cells were decreased in PR/Gal4 mice but failed to reach statistical significance (p=0.06, online supplemental figure 32 ).
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Progesterone promotes immunomodulation and tumor development in the murine mammary gland.
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Though the tumors from PR/Gal4 mice tended to be larger in size than those of the control mice, these data did not reach statistical significance ( figure 5A ).