A trend towards elevated protein carbonylation was also seen in isolated neural retina and more so in RPE-choroid fractions but these differences to wt did not reach statistical significance ( Fig. 1 A, bars retina, eyecup).
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Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction.
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The sentences
Both isolated neural retina and RPE/choroid show a trend toward increased protein oxidation as well that failed to reach statistical significance possibly due to sample to sample variability.