Burden of Renal Events Associated with Nonsteroidal Anti-inflammatory Drugs in Patients with Osteoarthritis and Chronic Low Back Pain: A Retrospective Database Study.

Pain Ther · 2021 · PMC8119512 · PMID 33439471

Europe PMC DOI

hedged sentences

0.0595

closest p · 1.2× alpha

0.0595

boldest claim

The sentences

showed a trendP = 0.0595so close (0.05 < p ≤ 0.1)

After adjusting the covariates, age, sex, and comorbidities in the multivariate analysis, the duration of treatment was a significant factor that increased the risk of developing renal events (> 1 to ≤ 3 years, risk ratio [RR] 1.2, 95% CI 1.12–1.54; P = 0.0007; > 3 to ≤ 5 years, RR: 1.38, 95% CI 1.04–1.84; P = 0.0254) while consistency of use was not statistically significant but showed a trend towards increasing the risk of developing renal events (RR: 1.24, 95% CI 0.99–1.55; P = 0.0595) (Table 3 ).

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did not reach statistical significanceno p-value reported

< 1 year) and consistent use (RR: 1.24, 95% CI 0.99–1.55; P = 0.0595) increased the risk of renal events but the latter did not reach statistical significance.

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