Phenotypic Differences between the Alzheimer's Disease-Related hAPP-J20 Model and Heterozygous <i>Zbtb20</i> Knock-Out Mice.

In the probe trial, Zbtb20 +/– mice showed a trend ( p = 0.06) toward favoring the target quadrant slightly less than WT mice ( Fig. 8 C ), but no significant differences were found between the groups during this component of the test in target preference index or mean proximity to the original platform location ( Fig. 8 D , E ).

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In the cortex of six-month-old hAPP-J20 mice, Zbtb20 mRNA levels were only slightly reduced and a trend toward Zbtb20 protein reduction did not reach statistical significance ( Fig. 6 E , F ).

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