MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer.

BMC Cancer · 2021 · PMC8136168 · PMID 34011306

Europe PMC DOI

hedged sentences

0.0618

closest p · 1.2× alpha

0.0618

boldest claim

The sentences

showed a trendp = 0.0618so close (0.05 < p ≤ 0.1)

The baseline expression of miR-3168 ( p = 0.0456, OR = 1.03, 95% CI: 1.00–1.06) and miR-4718 ( p = 0.0388, OR = 1.56, 95% CI: 1.03–2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend ( p = 0.0618, OR = 1.73, 95% CI: 0.98–3.29).

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did not reach statistical significanceno p-value reported

MiR-6125 did not reach statistical significance, with only a trend being observed, but showed an intermediate predictive performance when compared to miR-4718 and miR-3168 and had the best sensitivity (88.89) in predicting cisplatin-induced nephrotoxicity.

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