High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring.

Nutrients · 2021 · PMC8146511 · PMID 33925570

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.7000

boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

While the 1X folate offspring were also heavier than the 5X-FA offspring, these results did not reach statistical significance (~9%, p > 0.05).

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marginally significantp = 0.054so close (0.05 < p ≤ 0.1)

Additionally, a marginally significant form effect ( p = 0.054) on ambulatory activity during the light-cycle was found that was largely driven by lower activity in 5X-MTHF compared to the 5X-FA offspring, but similar to 1X offspring; potentially contributing to their higher weight gain [ 41 ].

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a strong trendp = 0.7not close (p > 0.1)

The form of folate also affected ambulatory activity as evidenced by a strong trend towards reduced activity that was mainly driven by the high MTHF form (Dose p = 0.7, Form p = 0.054, Dose×Form p = 0.09).

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