Recent meta-analytic reanalysis of this study, however, demonstrated a prophylactic effect of LI plus OXC, with a strong trend not only toward prevention of new depressive episode (RR 0.294, 95% CI 0.086–1.002) but also against new manic, hypomanic, or mixed episodes (RR 0.301, 95% CI 0.101–0.899) [ 74 ].
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Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder.
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The sentences
The percentage of the evaluable patients who had marked or moderate improvement on the Clinical Global Impression (CGI) scale was 33.3% on LI, 31.4% on CBZ, and 55.2% on the combination treatment, which was a clear trend but not significantly different between groups.