Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis.

Pharmaceutics · 2021 · PMC8151179 · PMID 34064771

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a strong trendno p-value reported

a weak trendno p-value reported

A strong trend of a decreasing fraction of the first peak was detected as the L/S ratio increases for API 1 5 and 50% as well as for API3 at 50% concentration, while a weak trend was found in API2.

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a clear trendno p-value reported

Regarding the kneading zones (C3, C5 and C6), as concluded in the original model, a clear trend was not observed for the parameters μ and σ during calibration, in the present work similar results were obtained [ 11 ].

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