Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis.

The differences in abdominal circumference and body mass index between the 5HT-sublines begin to become apparent at 3 months of age and become highly significant by 9.5 months of age (11%, p < 0.001, both) ( Figure 1 D,E).

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As shown in Figure 6 , adiponectin mRNA levels in WAT were upregulated in high-5HT compared to low-5HT animals (H/L = 1.21, p = 0.024), while differences in mRNA levels of leptin (H/L = 1.23) and complement factor D/adipsin (H/L = 1.16), although similar in magnitude, did not reach statistical significance ( Figure 6 A).

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Plasma and WAT levels of adiponectin showed a clear trend of negative correlation ( Figure S5C ).

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The results of qRT-PCR analysis confirmed that the mRNA levels of four of these genes were significantly higher in high-5HT animals compared with low-5HT animals, and one of these genes ( Adipor2 ) showed a nonsignificant trend in the same direction as in the array data ( Figure 7 C–G). 3.

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