Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism.

Nat Commun · 2021 · PMC8163740 · PMID 34050153

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did not reach statistical significanceno p-value reported

Our expression analyses using blood-derived RNA observed the same effect that, however, did not reach statistical significance, possibly because of low sample size (Supplementary Table 6A ).

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near-significantno p-value reported

The significance of the MSH3 -related locus—and the likely large effect that it exerts—are further supported by the near-significant effect that was observed in an even smaller-sized sample of HD patients ( n = 218; TRACK-HD cohort) 16 .

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