The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner.

Arthritis Res Ther · 2021 · PMC8173960 · PMID 34082814

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did not reach statistical significanceno p-value reported

After 3 days, both Th17/Th22 and DN cells expressed high levels of IL-17A mRNA, although the differences with Th17.1 and DP cells did not reach statistical significance.

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showed a trendno p-value reported

Directly after sorting, Th17/Th22 cells showed a trend towards being the strongest producers of IL-17A, IL-22, and GM-CSF, whereas Th17.1 and DP cells produced the highest levels of IFNγ (Fig. 1 B, upper panel).

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a decreasing trendno p-value reported

IL-8, MMP1, and MMP3 also showed a decreasing trend upon IL-17A neutralization.

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