Chromatin accessibility changes at intergenic regions are associated with ovarian cancer drug resistance.

Genes which showed reduced expression in the resistant lines had slightly reduced accessibility compared to the resistant lines, although this did not reach statistical significance ( t test p > 0.05) (Fig. 3 a, b).

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While this showed a trend towards similar pathways being altered in all three lines, only genes involved in regulation of the interferon gamma response and regulation of apoptosis were significantly dysregulated in all 3 lines (Additional file 1 : Fig.

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