Plasma lipidome is dysregulated in Alzheimer's disease and is associated with disease risk genes.

Transl Psychiatry · 2021 · PMC8180517 · PMID 34092785

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

did not reach statistical significancep = 0.063so close (0.05 < p ≤ 0.1)

Carriers of the APOE*4 allele, a strong genetic risk factor for AD risk, were more common in AD patients than controls, although this did not reach statistical significance (AD 37.5% vs. control 19%, χ 2 = 3.457, p = 0.063).

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nominally significantno p-value reported

However, the AD PRS × CC interaction was nominally significant ( p -value < =0.05) for 57 lipid species (Table 3 ), which were mainly PCs, SMs, and TGs.

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