Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU.

In addition, cells expressing 2N3R- and 0N3R-TAU D 2 had a significantly greater cell area than 4R-expressing cells (∼20%), comparable with untransfected cells, while 1N3R only showed a trend towards increased cell size compared with the 4R-TAU D 2 isoform-expressing cells (∼15% bigger cell size).

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In contrast, 3R-TAU D 2 isoforms showed no difference in microtubule counts compared with control cells, despite a slight trend towards a reduced number of microtubules for 0N3R.

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We observed several tendencies that, however, did not reach statistical significance: 1N- and 0N-TAU D 2 isoforms seem to cause a slight decrease in microtubule stability independent of the presence of the second N-terminal repeat ( Figure 2E ), and 2N4R-TAU D 2 seems to increase microtubule run length ( Figure 2F ).

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