Effect of the lysosomotropic agent chloroquine on mTORC1 activation and protein synthesis in human skeletal muscle.

At 2 h post ingestion, CHQ showed a trend for increased S6K1 phosphorylation of P = 0.07 compared to baseline (Fig. 4 B). 4E-BP1 (Thr37/46) phosphorylation was significantly increased ( P < 0.05) at 1 h post ingestion in both groups compared to baseline.

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In our study, we also found that the rate of whole body proteolysis was numerically less in the chloroquine group (e.g., 0.71 v 0.79 μmol/kg/min) at baseline, but this difference did not reach statistical significance.

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