Signs of chronic itch in the mouse imiquimod model of psoriasiform dermatitis: sex differences and roles of TRPV1 and TRPA1.

However, because of behavioral variability the effect size for imiquimod treatment failed to reach statistical significance when sexes were directly compared ( P = 0.0677).

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2E ), although the latter groups showed a nonsignificant trend toward increased scratching.

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Male and female TRPV1KO and male TRPA1KO mice exhibited significant increases in spontaneous scratching, and female TRPA1KO mice exhibited a tendency toward increased scratching which, however, did not reach statistical significance.

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