An Improved Detection of Circulating Tumor DNA in Extracellular Vesicles-Depleted Plasma.

Front Oncol · 2021 · PMC8226168 · PMID 34178690

Europe PMC DOI

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did not reach statistical significanceno p-value reported

Although the EV-depleted plasma fraction showed higher mutation detection rate than whole plasma (63.6% vs 45.5%), the difference did not reach statistical significance.

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a clear trendno p-value reported

By comparing different plasma fractions, we observed a clear trend of higher ctDNA content in fractions 3 (large EVs), 5 (exosomes) and 6 (EVs-depleted plasma).

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