Molecular determinants of response to PD-L1 blockade across tumor types.

Nat Commun · 2021 · PMC8233428 · PMID 34172722

Europe PMC DOI

hedged sentences

0.2300

closest p · 4.6× alpha

0.2300

boldest claim

The sentences

showed a trendp = 0.23not close (p > 0.1)

Conversely, increased CDK6 significantly associated with decreased OS in mUC (HR: 1.87, p < 0.01) and showed a trend toward lower OS in NSCLC (HR = 1.40, p = 0.23), and lower PFS in RCC (HR = 1.2, p = 0.5).

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did not reach statistical significanceno p-value reported

Decreased response to atezolizumab in tumors with CDKN2A loss was observed in mUC and RCC, yet this association did not reach statistical significance, possibly due to low sample size (Fig. 4c ).

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