The Effects of <i>N</i>-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol.

As can be seen in the figure—after intra-VTA EtOH administration—a clear trend toward the increase in the locomotor activity of animals, with respect to the aCSF/vehicle group (records increased from 1183 ± 430 to 1897 ± 480 cm), was observed.

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However, it is evident that, although the increase in cFOS was not statistically significant, there was a slight trend to increase the immunoreactivity of cFOS.

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pre-treatment with 120 mg/kg of NAC also showed a trend to attenuate the above-mentioned increase in the locomotor activity induced by ethanol.

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