Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures.

PLoS Genet · 2021 · PMC8244898 · PMID 34143769

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did not reach statistical significanceno p-value reported

A trend was noted toward decreased levels of total p70-S6K1 protein levels in both atp6v1e1b -deficient zebrafish, which did not reach statistical significance.

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showed a trendno p-value reported

Levels of phosphatidylethanolamine (PE) and the related 1- alkyl,2-acylphosphatidylethanolamines (PE-O), 1-alkenyl, 2-acylphosphatidylethanolamines (PE-P) and lysophosphatidylethanolamine (LPE) showed a trend to be upregulated in atp6v1e1b -deficient zebrafish compared to WT controls ( S7A–S7D Fig ).

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