Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease.

Alzheimers Dement · 2021 · PMC8247413 · PMID 33576571

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did not reach statistical significanceP = .25not close (p > 0.1)

showed a trendno p-value reported

Furthermore, we found that AD‐ɛ3 patients were depleted of high‐impact variants in HCε4‐iDEAL genes (Figure S2C , blue, P = .015; K‐S test) compared to HC‐ɛ3 and showed a trend for enrichment of high‐impact variants in ADɛ2‐iDEAL genes, though it did not reach statistical significance (Figure S2C , red, P = .25; K‐S test).

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