Analysis of the BAL cellular composition revealed a tendency towards a higher number of lymphocytes and neutrophils in Lamp3 -/- mice, which, however, did not reach statistical significance.
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The sentences
Interestingly, the transcript-levels of Sftpb and Sftpc were significantly reduced or showed a trend towards a decrease, while protein levels were distinctively increased, suggesting posttranslational mechanisms governing the increased stability thereby leading to higher steady-state protein levels: a finding that could hint towards a stabilizing effect of LAMP3.However, such a mechanism might not be essential and become relevant only under conditions where surfactant levels need to be regulated more tightly.