REP1 deficiency causes systemic dysfunction of lipid metabolism and oxidative stress in choroideremia.

Welch’s 2-sample t test (2 tailed) was used to identify compounds that differed significantly between CHM and healthy control study groups, with 85 named compounds achieving statistical significance ( P ≤ 0.05) and a further 48 approaching significance (0.05 < P < 0.10).

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FC values with P ≤ 0.05 and q ≤ 0.10 were considered statistically significant, while FC values with 0.05 < P < 0.10 were considered as trending toward significance.

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The chm ru848 zebrafish model showed a trend increase of cholesterol levels that were reduced following treatment with both statins and fibrates.

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