NK cells associate with ALS in a sex- and age-dependent manner.

The positive correlation between NKG2D and ALSFRS-R changes was higher in older versus younger subjects as was the association between NKp46 and ALSFRS-R changes ( Figure 4 ); a similar trend was observed with CD11b, though correlation differences only approached significance ( P = 0.0504).

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Similarly, a recent prospective clinical study found that increased overall immune levels in the periphery were associated with shorter survival in women with ALS than men, though these differences did not reach statistical significance ( 33 ).

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