Fasted adipo-P2Y 14 Δ/Δ mice showed a trend toward higher plasma FFA levels compared with fasted RC control mice, although this difference did not reach statistical significance ( P = 0.18; Supplemental Figure 2C ).
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Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis.
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Blockade of P2Y 14 R with PPTN showed a trend toward enhanced CL-316,243-mediated lipolysis (% increase: 25.96 ± 6.47), possibly due to increased cAMP level in cells ( Figure 1H ).