Mitochondrial Reactive Oxygen Species Enhance Alveolar Macrophage Activity against Aspergillus fumigatus but Are Dispensable for Host Protection.

mSphere · 2021 · PMC8265640 · PMID 34077261

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did not reach statistical significanceno p-value reported

In addition, intraleukocyte conidial viability was higher in p91phox −/− mCAT Tg/+ AMs (60% ± 2%) compared to p 91phox −/− (28% ± 7%) counterparts that had intact mtH 2 O 2 levels, though the difference did not reach statistical significance ( Fig. 4C ).

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a clear trendno p-value reported

The precise contribution and interdependence of NADPH oxidase and mtROS to AM anti- Aspergillus activity remain to be determined, though it is notable that both rotenone- or carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP)-treated macrophages in vitro ( 34 ) and mtH 2 O 2 -neutralized AMs in vivo both exhibit a clear trend to decreased antifungal activity when NADPH oxidase is either pharmacologically blocked (i.e., diphenyleneiodonium chloride [DPI]) or genetically ablated.

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