Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity.

J Clin Endocrinol Metab · 2021 · PMC8277223 · PMID 33864468

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.2700

boldest claim

The sentences

did not reach statistical significanceP = 0.05actually significant

IGF-I had a tendency to be lower in NFPA as compared with healthy controls although it did not reach statistical significance (D: 58 μg/L [48-88] vs E: 157 μg/L [113-189], P = 0.05 and D: 0.36 × ULN [0.26-0.51] vs E: 0.69 × ULN [0.61-0.80], P = 0.34).

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failed to reach significanceP = 0.27not close (p > 0.1)

IGF-I concentrations tended to drop in the patients classified as “discordant” after surgery (B2: 323 μg/L [169-394], 1.58 × ULN [0.78-1.76], C2: 284 μg/L [249-336], 1.40 × ULN [1.10-1.42]), but the change failed to reach significance (B2 vs A, P = 0.27; C2 vs A, P = 0.86).

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failed to reach statistical significanceno p-value reported

Both GH random and IGF-I tended to be lower in patients from the discrepant groups following treatment, but due to the large overlap with concentrations seen in treatment-naïve patients, the change failed to reach statistical significance.

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