Impact of sex on use of low tidal volume ventilation in invasively ventilated ICU patients-A mediation analysis using two observational cohorts.

Conclusion In these 2 large longitudinal projects spanning 2 decades of ventilation care for critically ill patients, we noticed a clear trend towards increased use of LTVV in females and males.

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Posthoc analyses The results of the posthoc analysis concerning 973 female and 1058 male patients with sepsis, did not change the findings, albeit that the differences did not reach statistical significance ( Fig 4 in S1 File ).

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