Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of urothelial cancer.

The interim analysis for OS showed a trend toward longer OS with the atezolizumab plus chemotherapy combination, which was not statistically significant (HR 0.83; 95% CI 0.69 to 1.00; one-sided p=0.027).

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Median OS was 22 months (95% CI 12.9 to not reached) with pembrolizumab and 18.7 months (95% CI 11.4 to not reached) with placebo, a secondary endpoint for which the trial was not adequately powered and did not reach statistical significance. 106 The JAVELIN Bladder 100 trial was a phase III, multicenter, multinational, randomized, open-label, parallel-arm study investigating first-line maintenance treatment with avelumab plus best supportive care (BSC) versus BSC alone in patients with mUC who did not have disease progression after first-line platinum-containing chemotherapy.

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