The severity progression of non-motor symptoms in Parkinson's disease: a 6-year longitudinal study in Taiwanese patients.

Sci Rep · 2021 · PMC8292315 · PMID 34285292

Europe PMC DOI

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showed a trendno p-value reported

676 patients completed the step 1 analysis, which showed a trend of NMSs worsening but not significant until the disease duration longer than 4–6 years.

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borderline significantno p-value reported

Only motor function (UPDRS Part III 19 to 27.5, p = 0.012) and sexual dysfunction (NMSS domain 8 score 2.24 to 0, p = 0.016) showed borderline significant differences.

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did not reach statistical significanceno p-value reported

The severity of NMSs of sleep and fatigue problems, perceptual function, attention and memory deterioration, and urinary difficulty also showed an increasing tendency, but this trend did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.