Temporal trajectory of biofluid markers in Parkinson's disease.

During the follow-up periods, entire PD patients showed an overall trend of decrease in CSF α-syn and Aβ 1-42 , whereas serum NfL were increased.

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Lower CSF α-syn and t-tau levels showed a trend of association with higher MDS-UPDRS III total scores at baseline, however, generalized linear models did not reach statistical significance (CSF α-syn, β = − 7.15, SE 3.85, p = 0.065; CSF t-tau, β = − 0.62, SE 0.34, p = 0.069). 311 PD patients showed MoCA total scores greater than 25 at baseline and were classified as PDNC.

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