Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.

Nonetheless, for t -test significant SNPs P emp not passing the Shapiro–Wilk test, we verified the result by checking for a nominally significant Mann–Whitney U test at p < 0.05.

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For SNPs with significant allele and interaction coefficients, a meaningful allele main effect was considered present if the single-condition vehicle and ATRA analyses showed the same allelic direction of effect, with a vehicle Pemp < 0.1 and ATRA FDR < 0.1 (i.e., near-significant within each condition of n = 6, thus reasonably capable of achieving significance in the LMM analysis of the two conditions combined).

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