Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

Antioxidants (Basel) · 2021 · PMC8300692 · PMID 34201806

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

almost reached statistical significancep = 0.058so close (0.05 < p ≤ 0.1)

Likewise, our nutrient combination may have influenced the FIS-40 cognitive domain, with a progressive improvement at the end of the treatment, which almost reached statistical significance ( Figure 3 B, p = 0.058), and also the overall FIS-40 score ( Figure 3 D, p = 0.079).

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did not reach statistical significancep = 0.058so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

As Figure 3 B shows, with regard to the cognitive domain, both groups evolved in parallel; however, unlike the placebo group, the melatonin plus zinc group showed a trend towards improvement that was maintained over the 16 weeks of treatment, although it did not reach statistical significance (16 weeks vs. baseline, p = 0.058).

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