Vocal Fold Fibroblasts in Reinke's Edema Show Alterations Involved in Extracellular Matrix Production, Cytokine Response and Cell Cycle Control.

The E2F transcription factor E2F1 just missed significance in RNA-seq (log2FC = −1.08, p -value = 0.0007, padj = 0.087).

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Likewise, qPCR analysis showed a trend toward downregulation, but missed significance ( p = 0.094) ( Figure 7 b).

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Though not significant, a clear trend towards lower levels of total TGF-β1 was visible ( Figure 3 d). 3.4.

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