Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia.

Biomedicines · 2021 · PMC8301488 · PMID 34356892

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showed a trendno p-value reported

Anti-mCRP Antibody 8C10 Palliated the Decrease of a Neural Plasticity Marker by mCRP at 6 Months of Treatment The injection of mCRP significantly decreased the levels of Egr1 mRNA in the hippocampus, as detected at 6 months of treatment, and 8C10 showed a trend to avoid loss of this plasticity marker by maintaining Egr1 levels in the same range as that of control-treated mice ( Figure 7 a) (one-way ANOVA, F (3, 17) = 3.525, p = 0.037).

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did not reach statistical significanceno p-value reported

The protective effect of antibody treatment did not reach statistical significance according to the post hoc analysis (mCRP + 8C10 did not differ from any other group).

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