Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer's Disease Model.

Biomolecules · 2021 · PMC8301787 · PMID 34356628

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

NOB showed a trend to restore bout duration, but the effect did not reach statistical significance.

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a slight trendno p-value reported

We did not observe statistically significant changes in behavioral period length ( Figure S1C,D ) or total activity ( Figure S1E ), although there may be a slight trend of period shortening in APP/PS1.Veh relative to WT.Veh, which was normalized by NOB ( Figure S1D ).

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